Encinitas, Calif.–(Newsfile Corp. – January 3, 2023) – Kiora Pharmaceuticals, Inc. (NASDAQ: KPRX) (“Kiora” or the “Company”) announced today that enrollment has been completed in its clinical study evaluating KIO-201 in patients with persistent corneal epithelial defects (“PCED”), a rare ocular condition characterized by non-healing sores on the surface of the eye. Results from the study are expected to be reported at an upcoming medical conference in the first half of 2023.

“This study is an important step in tackling some of the most challenging and difficult to treat corneal ulcers,” said Eric Daniels, M.D., Chief Development Officer at Kiora Pharmaceuticals. “Current standard of care for these patients is suboptimal in terms of outcomes and remains a significant burden on patients. We believe that KIO-201, an eye drop that can be easily administered at home, addresses many of these challenges. As part of our development strategy to address unmet and rare ophthalmic diseases, we have applied for Orphan Drug Designation of KIO-201 to the PCED.In addition, based on initial observations, we have begun planning discussions with the FDA for a Phase 3 registration study of KIO-201 in PCED.”

PCEDs are characterized by an inability of the cornea to properly repair the protective epithelial surface of the eye. This can be due to a number of underlying factors, including physical trauma, surgical injury, infections or inflammatory eye diseases. When the corneas are unable to heal, patients’ eyes are susceptible to recurrent infections, debilitating pain, scarring and reduced vision. It is estimated that there are fewer than 200,000 patients diagnosed annually in the United States with PCED[1].

The trial was designed as a single-arm, open-label study with ten patients (up to 20 eyes). Patients were evaluated at various time points up to 28 days after receiving KIO-201 six times daily. Endpoints included safety and tolerability︎, as well as the percentage of patients who achieved corneal healing and the associated time to complete corneal healing as determined by corneal fluorescein staining.

KIO-201 is a chemically modified, cross-linked form of the natural polymer Hyaluronic Acid (HA). HAs are involved in natural corneal healing but are thought to be limited by shortened ocular resonance time. Formulated as a convenient topical eye drop, KIO-201 provides a thin coating to the surface of the eye and serves as a protectant to facilitate and accelerate corneal re-epithelialization. The chemical modifications enable improved viscoelastic properties and prolong the ocular surface resonance time compared to standard hyaluronic acids.

Kiora Pharmaceuticals is a clinical-stage biotechnology company that develops and commercializes products for the treatment of ophthalmic diseases. KIO-301 is being developed for the treatment of retinitis pigmentosa. It is a molecular photoswitch that has the potential to restore vision in patients with hereditary and/or age-related retinal degeneration. KIO-101 is being developed for the treatment of the ocular presentation of rheumatoid arthritis (“OPRA”). It is a next-generation, nonsteroidal, immunomodulatory, small molecule inhibitor of Dihydroorotate Dehydrogenase (“DHODH”) with what Kiora believes is best-in-class picomolar potency and a validated immunomodulatory mechanism (blocking T-cell proliferation and proinflammatory cytokine release) designed to overcome the off-target side effects and safety concerns associated with commercially available DHODH inhibitors. In addition, Kiora is developing KIO-201, a modified form of the natural polymer hyaluronic acid, designed to accelerate corneal wound healing.

In addition to news releases and SEC filings, we expect to post information on our website, www.kiorapharma.com, and social media accounts that may be relevant to investors. We encourage investors to follow us on Twitter and LinkedIn as well as to visit our website and/or subscribe to email alerts.

Some of the statements in this press release are “forward-looking” and are made in accordance with the safe harbor provision of the Private Securities Litigation Reform Act of 1995. These “forward-looking” statements include statements regarding, among other things, results from this study that could support Kiora’s efforts to advancing KIO-201 to more advanced stages of clinical development, the expected timing of results from the study, KIO-201’s ability to address corneal wound treatment challenges, development and commercialization efforts and other regulatory or marketing approval efforts related to Kiora’s development-stage products; including KIO-101, KIO-201 and KIO-301, as well as the success thereof, with such approvals or success may not be achieved or achieved on a timely basis or at all. These statements involve risks and uncertainties that may cause results to differ materially from the statements in this press release, including, among other things, the ability to conduct clinical trials in a timely manner, market conditions and other conditions and certain risk factors described under the heading “Risk Factors” contained in Kiora’s amendment no. .1 to Annual Report on Form 10-K/A filed with the SEC on July 7, 2022 or described in Kiora’s other public filings. Kiora’s results may also be affected by factors of which Kiora is not currently aware. The forward-looking statements in this press release speak only as of the date of this press release. Kiora expressly disclaims any obligation or undertaking to publish any update or revision of such statements to reflect any change in its expectations with respect thereto or any change in the events, conditions or circumstances on which such statement is based, except as required by law.

Investor ContactFrancina Agosti, PhD(617) 546-0742fagosti@reportablenews.com

[1] Vaidyanathan U, Hopping GC, Liu HY, et al. Persistent corneal epithelial defects: A review article. With Hypothesis Discov Innov Ophthalmol. 2019;8(3):163-176.

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/150107

Icosavax has received a consensus rating of Buy. The company’s average rating score is 3.00 based on 1 buy rating, no hold ratings and no sell ratings.

What is next for Allakos?

Upcoming Allakos Milestones Complete IND-enabling studies of AK006 during 2022 and initiate the first-in-human study in the first half of 2023. Report top-line data from the Phase 2 study of subcutaneous lirentelimab in patients with atopic dermatitis in the second half of 2023.

Is Allakos a good investment? Allakos has an upside potential of 87.34%, based on analysts’ average price target. Can I see which stocks the top analysts are rating? Yes, go to the Analyst’s Top Stocks tool to see stocks with a strong buy or strong sell analyst rating consensus according to the top performers.

Is ALLK a good stock?

Its value score of F indicates that it would be a poor choice for value investors. ALLK’s financial health and growth prospects demonstrate its potential to underperform the market.

Will ALLK stock bounce back?

ALLK – Uptrend! DA: The stock is likely to hit the lower bullish trend line and possibly bounce back to reach the $48.00 target in the coming weeks.

Why ALLK stock is down?

Allako’s (ALLK 0.61%) stock sank 87.5% in December, according to data from S&P Global Market Intelligence. The clinical biotech company’s share price fell after the release of disappointing trial data for its most important treatment.

What happened to Allakos Inc?

What happened. Allako’s (ALLK -2.99%) stock sank 87.5% in December, according to data from S&P Global Market Intelligence. The clinical biotech company’s share price fell after the release of disappointing trial data for its most important treatment.

Will Allakos go back up?

The average Allak stock price prediction predicts a potential upside of 379.48% from the current ALLK stock price of $7.94.

When did Allakos go public?

The shares are expected to begin trading on the Nasdaq Global Select Market today under the symbol “ALLK.†The offering is expected to close on July 23, 2018, subject to the satisfaction of customary closing conditions.

Will Allakos go back up?

The average Allak stock price prediction predicts a potential upside of 379.48% from the current ALLK stock price of $7.94.

Why did Allakos drop so much?

Disappointing trial data for Allakos’ lirentelimab monoclonal antibody crushed the stock.

Will Allakos stock recover?

ALLK Stock 12-Month Forecast Based on 3 Wall Street analysts offering 12-month price targets for Allakos for the past 3 months. The average price target is $14.50 with a high forecast of $20.00 and a low forecast of $9.00. The average price target represents a change of 87.34% from the last price of $7.74.

Should I buy AeroClean stock?

AeroClean Technologies has received a consensus rating of Buy. The company’s average rating score is 3.00 based on 1 buy rating, no hold ratings and no sell ratings.

Should I buy LianBio shares? According to 10 equities analysts, the average 12-month stock price forecast for LianBio stock is $9.92, predicting an upside of 624.09%. The lowest target is $2.95 and the highest is $15.75. On average, analysts rate LianBio stock as a buy.

Will AeroClean stock go Up?

Stock Price Forecast The 1 analysts offering 12-month price forecasts for AeroClean Technologies Inc. have a median target of 7.00, with a high estimate of 7.00 and a low estimate of 7.00. The median estimate represents a 116.72% increase from the last price of 3.23.

What is the future of OCGN stock?

On average, Wall Street analysts predict that Ocugen stock price could reach $5.88 by August 23, 2023. The average Ocugen stock price prediction predicts a potential upside of 351.92% from the current OCGN stock price of $1.30.

Is AERC a good stock to buy?

According to 7 equities analysts, the average 12-month stock price forecast for AERC stock is $7.14, predicting a 134.87% upside. The lowest target is $7.07 and the highest is $7.35. On average, analysts rate AERC stock a buy.

Is AERC a good stock to Buy?

According to 7 equities analysts, the average 12-month stock price forecast for AERC stock is $7.14, predicting a 134.87% upside. The lowest target is $7.07 and the highest is $7.35. On average, analysts rate AERC stock a buy.

Should I buy AERC stock?

There is currently 1 buy rating for the stock. The consensus among Wall Street analysts is that investors should “buy” AERC stock. View AERC analyst ratings or view top rated stocks.

Is ENIC a buy?

ENIC stock is holding buy signals from both short- and long-term moving averages, giving a positive outlook for the stock.

Is XFLS a good stock to buy?

If you are looking for stocks with good returns, Xfuels Inc can be a profitable investment opportunity. Xfuels Inc price is equal to 0.00440 USD on 2022-12-29. Based on our forecasts, a long-term increase is expected, "XFLS" Stock price forecast for 2027-12-22 is $1.457.

Should I buy Deftf shares? 1 Wall Street analysts have issued “buy”, “hold” and “sell” ratings on Valor in the last twelve months. There is currently 1 buy rating for the stock. The consensus among Wall Street analysts is that investors should “buy” DEFTF stock.

Should I buy ICOA stock?

If you are looking for stocks with good returns, ICOA Inc can be a profitable investment opportunity. ICOA Inc price is equal to 0.00140 USD per share. 2023-01-02. Based on our forecasts, a long-term increase is expected, “ICOA” stock price forecast for 2027-12-27 is $0.01091.

Will Silvergate stock go up?

Share Price Forecast The 10 analysts offering 12-month price forecasts for Silvergate Capital Corp have a median target of 35.50, with a high estimate of 150.00 and a low estimate of 24.00. The median estimate represents an increase of 115.67% from the last price of 16.46.

Should you buy Bodystock?

Is Beachbody Company Stock a Good Buy in 2022, According to Wall Street Analysts? The consensus among 3 Wall Street analysts covering (NYSE:BODY) shares is to Buy BODY shares.

Will Humanigen go up?

Stock Price Forecast The 2 analysts offering 12-month price forecasts for Humanigen Inc. have a median target of 4.75, with a high estimate of 9.00 and a low estimate of 0.50. The median estimate represents an increase of +3,858.33% from the last price of 0.12.

Should I invest in Humanigen? 4 equities research analysts on Wall Street have issued “buy”, “hold” and “sell” ratings on Humanigen in the last year. There are currently 1 sell rating and 3 hold ratings for the stock. The consensus among Wall Street equity analysts is that investors should “hold” HGEN stock.

Will HGEN stock go back up?

The average Humanigen stock price prediction predicts a potential upside of 1,718.18% from the current HGEN stock price of $0.11. What is HGEN’s forecast for earnings per share (EPS) for 2022-2024?

What is the future of OCGN stock?

On average, Wall Street analysts predict that Ocugen stock price could reach $5.88 by August 23, 2023. The average Ocugen stock price prediction predicts a potential upside of 351.92% from the current OCGN stock price of $1.30.

Why is HGEN stock down?

The drop came after the clinical-stage biopharmaceutical company announced Thursday that the U.S. The Food and Drug Administration denied emergency use authorization for lenzilumab for the treatment of newly hospitalized COVID-19 patients.

Why is HGEN stock down?

The drop came after the clinical-stage biopharmaceutical company announced Thursday that the U.S. The Food and Drug Administration denied emergency use authorization for lenzilumab for the treatment of newly hospitalized COVID-19 patients.

Should I buy HGEN stock?

4 Wall Street research analysts have issued “buy”, “hold” and “sell” ratings for Humanigen in the last twelve months. There are currently 1 sell rating and 3 hold ratings for the stock. The consensus among Wall Street analysts is that investors should “hold” HGEN stock.

Will Humanigen go up?

Stock Price Forecast The 2 analysts offering 12-month price forecasts for Humanigen Inc. have a median target of 4.75, with a high estimate of 9.00 and a low estimate of 0.50. The median estimate represents a 3,858.33% increase from the last price of 0.12.

Will HYZN stock go up?

Stock Price Forecast The 1 analysts offering 12-month price forecasts for Hyzon Motors Inc. have a median target of 4.00, with a high estimate of 4.00 and a low estimate of 4.00. The median estimate represents a 148.45% increase from the last price of 1.61.

What is the best stock to make money?

The best income stocks have consistently increased their cash payouts over time….Here’s a look at some of the best income stocks to consider:

• Wm. WM (NYSE:WM) excels at turning waste into cash for its investors. …
• Verizon. …
• Microsoft. …
• Property income. …
• NextEra Energy.

Is $1000 enough to invest in stocks?

$1,000 is enough to make a single stock purchase through an online brokerage reasonable. You lose some money on the transaction itself, but the right stock can return many times the transaction costs.